Siriraj Metabolomic and Phenomic Center

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Proteomics is a new large-scale study for systematically analyzing type, quantity, and function of proteins. Proteomics has been applied in medical research to help scientists understand pathogenesis of a disease that leads to biomarkers. This makes diagnosis faster and more accurate, resulting in better treatment efficiency and less complications and may finally lead to new medicine or vaccine with greater efficiency in treatment and prevention of a disease.

In Thailand, Proteomics has been focused on proteomics of common diseases and diseases with high healthcare, economic and societal burden. The main objectives are to diagnose, treat and monitor such diseases like diabetes, kidney stone, Dengue fever, Leptospirosis, Melioidosis, Alzheimer’s disease and thalassemia.

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Therapeutic Protein and Antibody Production and Engineering

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Public health research continues to be an area of intense interest at Siriraj Hospital. Recent and ongoing technological advancements are focusing on proteins, antibodies, the genome, and proteomics. Given that antibiotics resistance is a developing health threat in Thailand, the Faculty of Medicine Siriraj Hospital is strengthening its efforts in the areas of genomics and alternative treatments for infectious diseases.
One of the Faculty of Medicine’s specialists who has dedicated a significant portion of her research to this area of study is Prof. Wanpen Chaikampa of the Department of Parasitology. Prof. Wanpen has more than 10 years of experience in immunology and human genes that produce antibodies that can block the virus protein production that causes influenza.

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Siriraj Clinical Research Center

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These services are provided by staff members who have been GCP-trained and
have clinical research skills and experience. Other services provided by the Clinical

Research Center are:
• Research feasibility study
• Proposal preparation for efficacy  assessment of all medical products
• Cost appraisal for bioequivalence study of generic formulation of drugs and phase 1 clinical trials
• Recruitment of research assistants of all levels, including research nurses, pharmacists, scientists and research project coordinators for multicenter study
• Recruitment of research participants for phase 2 to 4 clinical trials
• Research personnel training on clinical research according to the Good Clinical Research Practice (GCP)
guideline
• Coordination for collection and delivery of research samples from research participants to national and
international laboratories The Siriraj Clinical Research Center is located on the 10th floor, His Majesty the King’s 80th Birthday Anniversary 5th December 2007 Building. The SiMR is capable to provide biomedical and clinical research-related services to all research units within the Faculty of Medicine Siririaj Hospital as well as various government and private organizations.

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Center of Applied Thai Traditional Medicine

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The Center of Applied Thai Traditional Medicine, Faculty of Medicine Siriraj Hospital, has many responsibilities. The Center provides applied Thai traditional medicine education and related services, as well as the manufacturing of herbal medicines.

Another important responsibility is to conduct formal research and development for the purposes of advancing Thai traditional medicine and further promoting its acceptance and use among the Thai general public.

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Integrated Center of Excellence Diabetes Mellitus

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Globally, the prevalence oftype 2 diabetes is growing at an alarming rate around 280 million people at 2010, and then prospectively increases to 450 million people in next 20 years.

(1) Moreover, prevalence of diabetes in Thailand is around 6.9%

(2) and is projected to increase more than 46% (Western Asia Pacific) in that 20-year period.Similarly, there was an upward trend in the number of outpatient diabetes visits in Siriraj Hospital, from approximately 45,000 patients in 2011 to 51,000 patients in 2014. In addition, 12,000 new patients per year are referred to the center for diabetes and complication management from all over Thailand

(3) Consequently, diabetes will be a major problem and burden in Siriraj hospital, and will require excellent systematic diabetes service and diabetes self-management education and support and will provide many research opportunities in many aspects.

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Allergy and Immunology – House Dust Mite Vaccine

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Over the past 30 years, the occurrence of allergies, especially respiratory allergies like asthma and allergic rhinitis, have been dramatically increasing around the world.

In Thailand, asthma is found in 15% of children and 5% of adults, with rates of allergic rhinitis as high as 40% in children and 26% in adults. Accordingly, allergies are the main cause of acute and chronic respiratory disease among Thai people.

There are currently an estimated 18 million Thai people suffering from allergies. Consistent with the scope of the prevalence, the cost of treating allergy patients is estimated to be as high as THB 2,250 million per year.

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Siriraj Thalassemia Center

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Thalassemia is the most prevalentgenetic disease in Thailand.Approximately 35% of the Thaipopulation (18-20 million people) arecarriers. The Faculty of Medicine SirirajHospital is the world’s pioneer non-Mediterranean thalassemia research institute a distinction Siriraj has upheld since 1950.

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Geriatics

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The increasing life expectancy in Thailand’s population translates into a higher demand for age-specific health care. Senior citizens have health problems and disease progression that are different from patients in other age groups. Geriatric medicine and research allows doctors to understand, manage, and anticipate physical changes, health problems, and rehabilitation needs related to Thailand’s senior population. The Faculty of Medicine Siriraj Hospital continues to focus on research that promotes improved health and the prevention of serious diseases that are common to Thailand’s senior population. Research topics include :

  • Dementia in senile people research,which investigates more effective ways to diagnose and treat dementia patients. Assoc. Prof. Dr. Worapan and Assoc. Prof. Dr. Weerasak
    Muangpaisan of the Department of Medicine are leading this study.
  • Geriatric research that endeavors to find better health promotion strategies and methods for prevention of common diseases in seniors. This research study was undertaken by Assoc. Prof. Dr. Prasert Assantachai of the Department of Preventive and Social Medicine. This research was later expanded into easy-to-read books on how to take better care of the elderly. These books have been well received by Thailand’s community of family caregivers.

Siriraj Center of Research for Excellence consist of Research network and Research group

  • Center of Excellence for perioperative anesthesia care in geriatrics
  • Research group : Neuro disorders ( dementia )
  • Research group : Muscular disorders
  • Research group : Siriraj and SCG Home solution contact point

This collaboretive is from

  • Department of Emergency Medicine
  • Department of Forensic Medicine
  • Department of Medicine
  • Department of Orthopaedic Surgery
  • Department of Preventive and Social Medicine

 

Siriraj Initiative in Systems Pharmacology (SISP)

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Advancement in the 21st century is revolutionizing medicine to be more precise and clinically tailored for individual patients. While we are equipped with more efficient drugs, choosing the right drug choice for a specific subgroup of patients is still an active area of research. In the past few years, more reports have shown that ethnicity contributes significantly towards the heterogeneous drug response. Understanding how the genetic backgrounds are associated with commonly observed variability in therapeutic sensitivity will help fulfill this critical research gap. More information